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Cell-Free Sampling Probes

Sterile In-situ Sampling System for Fermentation and Cell Culture

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Flownamics® Analytical Instruments has developed a sampling probe capable of withdrawing sterile, cell-free samples from fermentors and bioreactors. The FISP® probes not only allow off-line sampling, but also direct on-line sample transfer to biochemical or other types of analyzers. The FISP® sampling probe is a small tube-shaped sterilizable 316 stainless steel carrier surrounded by a tubular micro-porous membrane. The probes are available for 12, 19 and 25 mm ports, for laboratory, pilot or industrial scale vessels.

FEATURES OF THE FISP®

  • Sterile, cell-free sampling for off-line and on-line analysis
  • FISP® Probes can be autoclaved or sterilized in-place
  • Used for aerobic or anaerobic bacterial cultures, as well as yeast, fungi, algae, insect, animal and mammalian cell cultures
  • Risk free sampling due to elimination of bypass filters, which circulates material back into vessel
  • Accommodates small laboratory vessels up to large full-scale production vessels with 12, 19 and 25 mm models
  • Easy to use and maintain; no operator training required
  • Interfaces the fermentor or bioreactor with a variety of analytical systems
    • Biochemistry Analyzers
    • Fraction collectors, Autosamplers
    • Methanol analyzers
    • Flow Injection Analysis (FIA)
    • HPLC
    • Biosensors
    • Ion Chromatography
    • Mass spec systems
  • Design minimizes dead volume, which allows for consistent and accurate sampling, and reduces probe flush time
  • Durable in design and construction to withstand the temperatures, pressures, viscosities, shear forces and chemicals typical of fermentation environments


Materials

  • Probes and fittings are 316 stainless steel
  • O-rings are Ethylene Propylene (EPDM)
  • Membranes materials are Polypropylene & Ceramic

 

 

 

 

 

 

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